The Alpillo Plate Cushion compensates for physical tolerances between labware and pipettor that can make automated precision pipetting difficult. Labware variations, misaligned pipet heads, calibration errors, mechanical wear, or tip loading variability are but a few of the problems that often lead to inaccurate positioning between tips and labware. Whether the task is to get the last microliter out of a well, or to touch off small volumes in a dry well, the Alpillo makes these tasks easy by providing flexible plate support.
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The Alpillo Extension is used to increase the height of the Alpillo by 7.5 mm to make it suitable for deeper plate nests like those found on the Biomek® 2000/3000, or Perkin Elmer® Janus® plate nests (same as MultiProbe® II). Easy installation with four screws (included); simply attach it to the bottom of the Alpillo.
The patented* Alpillo Plate Cushion is designed to compensate for physical tolerances between labware and pipettor that can make automated precision pipetting difficult. Labware tolerances, tip loading variations, calibration errors, mechanical wear, or heat-related shrinkage and warping are but a few of the problems that often lead to inaccurate positioning between pipet heads and tips. The Alpillo helps you avoid these problems.
Alpaqua designs products and solutions to expand and improve the functionality of your automated liquid handling equipment. By leveraging our knowledge of the instrument and its capabilities, we find new and innovative ways to approach challenging automation tasks – sometimes with surprising results.
The Alpillo improves pipetting results whenever the tips need to come close to the well bottoms. Microplates supported by the Alpillo give way, thus limiting the force exerted by the tips as they push down.
The Alpillo Plate Cushion is indispensable in all applications where fluid needs to be completely removed from a well, like in wash or supernatant removal steps. In these situations the tips must eventually reach the bottom, which is hard to do reproducibly in stiff, immovable systems without risking pushing too hard. Here the Alpillo really shines by providing the much needed elasticity that allows for a wide range of possible height variations.
By providing a flexible microplate support the Alpillo protects pipet heads and consumables alike and makes it easy to aspirate right down to the last microliter without concern about bending tips and compromised pipetting. It pays for itself in short time by preventing costly tip crashes that lead to loss of valuable sample or reagents, loss of time, and loss of the tips themselves.
Finding the well bottom is crucial to successful pipetting in low volume applications. The Alpillo helps by providing visual feed-back as the tips touch down and slightly compress the plate's spring-loaded support, as can be seen impressively in the video above.
With 2 mm of travel the resetting forces of the springs are weak enough to effectively prevent tips from being sealed off. This ensures that no vacuum will build up in the tips.
Without vacuum, no sample will shoot into the tips upon withdrawal. This means no contamination of the mandrels or filters in barrier tips.
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